ATP as a mediator of macula densa cell signalling
نویسندگان
چکیده
منابع مشابه
Macula densa cell signaling.
Macula densa cells are renal sensor elements that detect changes in distal tubular fluid composition and transmit signals to the glomerular vascular elements. This tubuloglomerular feedback mechanism plays an important role in regulating glomerular filtration rate and blood flow. Macula densa cells detect changes in luminal sodium chloride concentration through a complex series of ion transport...
متن کاملAdenosine as a mediator of macula densa-dependent inhibition of renin secretion.
Adenosine acting through A(1) adenosine receptors (A1AR) has been shown previously to be required for the vasoconstriction elicited by high luminal NaCl concentrations at the macula densa (MD). The present experiments were performed to investigate a possible role of A1AR in MD control of renin secretion in conscious wild-type (WT) and A1AR-deficient mice. The intravenous injection of NaCl (5% b...
متن کاملMacula densa cell signaling involves ATP release through a maxi anion channel.
Macula densa cells are unique renal biosensor cells that detect changes in luminal NaCl concentration ([NaCl](L)) and transmit signals to the mesangial cellafferent arteriolar complex. They are the critical link between renal salt and water excretion and glomerular hemodynamics, thus playing a key role in regulation of body fluid volume. Since identification of these cells in the early 1900s, t...
متن کاملMacula densa-dependent and non-macula densa-dependent signaling in the juxtaglomerular apparatus
................................................................................................................. 75 ABSTRACT IN HUNGARIAN (ÖSSZEFOGLALÁS) ............................................ 76IN HUNGARIAN (ÖSSZEFOGLALÁS) ............................................ 76
متن کاملMacula densa basolateral ATP release is regulated by luminal [NaCl] and dietary salt intake.
One component of the macula densa (MD) tubuloglomerular feedback (TGF) signaling pathway may involve basolateral release of ATP through a maxi-anion channel. Release of ATP has previously been studied during a maximal luminal NaCl concentration ([NaCl](L)) stimulus (20-150 mmol/l). Whether MD ATP release occurs during changes in [NaCl](L) within the physiological range (20-60 mmol/l) has not be...
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ژورنال
عنوان ژورنال: Purinergic Signalling
سال: 2009
ISSN: 1573-9538,1573-9546
DOI: 10.1007/s11302-009-9148-0